5 Questions about Hydroxychloroquine and COVID-19

                What is hydroxychloroquine? 

                Hydroxychloroquine is a medicine indicated in some rheumatological and dermatological diseases such as rheumatoid arthritis and lupus. In some countries, it is also indicated in the prevention or treatment of malaria.

                It has been developed in the 1950s from chloroquine, an old anti-malarial drug.

                Hydroxychloroquine can cause serious adverse reactions and should not be taken without medical prescription or advice.

                Sanofi’s hydroxychloroquine product is not indicated for use in COVID-19 in any country. 

                For more information about hydroxychloroquine, click HERE.

                Hear from Sandra Silvestri, Global Medical Head, General Medicines at Sanofi

                What is Hydroxychloroquine?

                Why do we keep hearing about it today? 

                According to some preliminary results from independent pilot studies, hydroxychloroquine was reported as having a potential anti-viral effect on the virus that causes COVID-19.

                It is too early to say if hydroxychloroquine has the potential or not to treat COVID-19. Today, there is insufficient clinical evidence to draw any conclusion. Large clinical studies are being conducted to assess the safety and efficacy of hydroxychloroquine in COVID-19 patients.


                Where do we stand today?

                The World Health Organization (WHO) announced an international clinical trial called “Solidarity” to investigate the use of several medicines, including hydroxychloroquine, in the management of COVID-19. 

                In addition, several independent trials are being conducted in parallel in different countries to find answers to many questions on the use of this medicine in COVID-19 as fast as possible.

                At Sanofi, we are doing our part to support this international effort. We are conducting two clinical studies on hydroxychloroquine. We are also providing the medicine for free to research centers participating in the WHO trial and other researchers, upon their request.

                Hear from Sandra Silvestri, Global Medical Head, General Medicines at Sanofi

                COVID-19 and Hydroxychloroquine:<br>Where do we stand today?

                A clinical trial: How does it work? How long does it take? 

                A clinical trial (or study) normally takes place after in vitro and animal studies (preclinical testing) have proved satisfactory. Often, the medicine is compared to a placebo (a substance with no pharmacological activity) or to existing treatments, to determine whether it is effective. It determines the effective dose regimen, possible toxicity and the nature and frequency of adverse events it may cause.  It usually lasts a couple of years.

                Click on the following links to know more about clinical trials and the different phases:

                When will we have concrete answers?

                The medical and scientific community is working at full speed to find answers about potential solutions, including hydroxychloroquine and other medicines.

                We may start to have preliminary results from ongoing clinical studies in the coming weeks.

                It is important to act fast, but it is equally important to take all the necessary precautions to ensure patient safety.

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